Role of epigenetic modifyers MBD2 and TET proteins in DNA methylation and demethylation in cancer [ 2012 - 2014 ]

Research Grant

Researchers: Prof Susan Clark (Principal investigator) ,  Dr Clare Stirzaker

Brief description Cancer is a disease of both genetics and epigenetics, the cell machinery that controls how the DNA code is read. DNA methylation is one part of epigenetics but few studies have investigated how the loss of methylation contributes to cancer formation. We have exciting new data that implicates specific proteins in this process and, with this funding we will determine how these proteins affect gene regulation in cancer, potentially leading to novel cancer diagnosis and treatment strategies.

Funding Amount $AUD 722,068.29

Funding Scheme Project Grants

Notes Standard Project Grant