The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis [ 2015 - 2017 ]

Research Grant

Researchers: Prof Stan Gronthos (Principal investigator) ,  Dr Agnieszka Arthur ,  Prof Andrew Zannettino

Brief description The present proposal will identify the importance of ephrinB1 during the deregulation of bone remodelling that occurs in osteoporosis, by deleting ephrinB1 in committed osteoblast precursor cells in a mouse model of osteoporosis. Knowledge gained from this proposal could potentially translate into alternative therapeutic treatment strategies for patients with osteoporosis with the use of Eph/ephrin targeted drugs currently being developed for cancer treatment.

Funding Amount $AUD 567,292.50

Funding Scheme Project Grants

Notes Standard Project Grant