grant

Role in disease of a novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44 [ 2012 - 2016 ]

Also known as: Role in disease of a specific protein, a DNA methylase, that is present in strains of Neisseria meningitidis that cause high levels of meningococcal disease

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1021631]

Researchers: A/Pr Kate Seib (Principal investigator) ,  Dr Rino Rappuoli

Brief description Neisseria meningitis is a major cause of meningococcal septicaemia and meningitis worldwide. We have identified a phase variable DNA methyltransferase present in disease isolates, some of which have caused meningococcal epidemics. This methyltransferase is involved in the regulation of proteins involved in infection and disease processes. We will investigate whether this regulation increases the ability of the bacteria to adapt to changing host environments and cause disease.

Funding Amount $AUD 403,249.30

Funding Scheme Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Identifiers
Viewed: [[ro.stat.viewed]]