grant

The role of the dendritic cell surface molecule Clec9A in dendritic cell subset function and dead cell recognition [ 2009 - 2011 ]

Also known as: The role of a novel cell surface molecule, Clec9A, in immune function

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/575546]

Researchers: Prof Ken Shortman (Principal investigator) ,  A/Pr Irina Caminschi ,  A/Pr Mireille Lahoud

Brief description Dendritic cells (DC) are sentinels of the immune system. DC monitor the environment and regulate tolerance to self versus immunity to dangerous material. Different types of DC perform different jobs. We have identified a new surface molecule, Clec9A, on some mouse and human DC. We will investigate the function of Clec9A in the immune response. We will also use Clec9A to help unite mouse and human DC biology, since until now there have been few useful marker molecules common to both species.

Funding Amount $AUD 526,878.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Clinical Chemistry (Incl. Diagnostics) | Clinical Sciences | cell death | cell surface recptor | dendritic cell | dendritic cells | immune regulation | immune responses | immunology |
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ACN 633 798 857