The role of the cytoskeleton in communication between the L-type Ca2+ channel and the mitochondria in cardiac pathology [ 2010 - 2013 ]

Also known as: How does the calcium channel regulate energy requirements in heart cells

Research Grant

[Cite as]

Researchers: A/Pr Livia Hool (Principal investigator) ,  A/Pr Aleksandra Filipovska Prof Nigel Laing Prof Christopher Semsarian

Brief description The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for maintaining normal rhythm and contraction. We have shown that the channel can also regulate the function of the energy producing part of the cell (mitochondria). This occurs with the assistance of proteins that maintain cell architecture. We will test whether this association is altered in human disease where the cell architecture is disrupted to determine the mechanisms for poor energy supply.

Funding Amount $AUD 542,890.16

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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