The role of the cytoskeleton in communication between the L-type Ca2+ channel and the mitochondria in cardiac pathology [ 2010 - 2013 ]

Research Grant

Researchers: A/Pr Livia Hool (Principal investigator) ,  A/Pr Aleksandra Filipovska ,  Prof Christopher Semsarian ,  Prof Nigel Laing

Brief description The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for maintaining normal rhythm and contraction. We have shown that the channel can also regulate the function of the energy producing part of the cell (mitochondria). This occurs with the assistance of proteins that maintain cell architecture. We will test whether this association is altered in human disease where the cell architecture is disrupted to determine the mechanisms for poor energy supply.

Funding Amount $AUD 542,890.16

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant