grant

The Role of Connexin40 in the Pathogenesis of Atrial Fibrillation Probed by Targeted In Vivo Gene Transfer [ 2008 - 2011 ]

Also known as: Atrial Fibrillation and Connexin40

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/503802]

Researchers: Dr Eddy Kizana (Principal investigator)

Brief description Atrial fibrillation (AF) is a fast and irregular heart rhythm that can predispose sufferers to heart failure and stroke. AF occurs as the result of abnormal electrical conduction in the upper heart chambers. We have found that a protein called Cx40 causes abnormal conduction in heart cells when grown in culture. The aim of this research is to see if AF occurs when Cx40 is increased and prevented when Cx40 is decreased in an AF animal model, potentially defining Cx40 as new therapeutic target.

Funding Amount $AUD 529,015.81

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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Subjects
Arrhythmia | Atrial Fibrillation | Biomedical and Clinical Sciences | Conduction | Connexin | Gap Junction | Gene Transfer | Nutrigenomics and Personalised Nutrition | Nutrition and Dietetics | cardiovascular disease |
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