Role of common genetic variation driving single cell transcriptional heterogeneity across the cardiomyocyte lineage [ 2018 - ]

Research Grant

Researchers: A/Pr Joseph Powell (Principal investigator) ,  Dr Matthew Ritchie ,  Dr Nathan Palpant

Brief description In human tissues, most mature cells develop by differentiation from pluripotent stem cells. As they undergo differentiation, their transcriptional activity changes dramatically. Many of the genetic causes for these changes are unknown, which limits research in the use of stem cells for treating and modelling disease. This proposal addresses this problem with cardiac muscle cell differentiation by utilising recent developments in biotechnology that enables individual cells to be sequenced.

Funding Amount $882,698.00

Funding Scheme Project Grants

Notes Standard Project Grant