The role of clathrin in the spindle assembly checkpoint and as an anti-cancer target [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr Megan Chircop (Principal investigator) ,  Dr Jennette Sakoff ,  Prof Adam Mccluskey ,  Prof Phillip Robinson

Brief description Cell division produces two daughter cells. Incorrect localisation and modification of proteins that regulate mitosis cause errors that can lead to cancer. As well as using a unique machinery mitosis uses proteins involved in non-cell cycle pathways. This project investigates the role during mitosis of one such protein: clathrin. We will identify lead clathrin inhibitory compounds, pitstops, that have potential anti-cancer properties, ultimately to be used as a chemotherapy agent.

Funding Amount $AUD 651,768.53

Funding Scheme Project Grants

Notes Standard Project Grant