Role of chromatin remodelling in diabetic renal and vascular complications: in vivo studies [ 2009 - 2011 ]

Research Grant

Researchers: Prof Mark Cooper (Principal investigator) ,  Prof Assam El-Osta ,  Prof Karin Jandeleit-Dahm

Brief description Even after diabetics return to improved blood glucose levels after a period of poor blood glucose control, the kidney and blood vessel complications progress. The cause of this metabolic memory remains unexplained. This proposal focuses on sustained changes as a result of prior glucose levels in proteins called histones that are part of the wrapping of DNA. Using a new technique called carrier ChIP we will study histone modifications in the blood vessels and kidneys in diabetes.

Funding Amount $AUD 474,618.53

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant