Role of the CD8-Heparan Sulfate Interaction in CD8+ T cell Development and Function [ 2015 - ]

Research Grant

Researchers: Prof Christopher Parish (Principal investigator) ,  Prof Ed Palmer

Brief description The immune system can recognise a large array of foreign pathogens without reacting to self-components. For this to occur T cells, the main mediators of immunity, must be made to tolerate self-molecules as they develop in the thymus. We have identified a novel interaction between a molecule called CD8 on T cells and a complex carbohydrate called heparan-sulfate, which helps auto-reactive T cells to be eliminates in the thymus. The aim of this project is to further investigate this phenomenon.

Funding Amount $628,813.00

Funding Scheme Project Grants

Notes Standard Project Grant