Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/301084]Researchers: Dr Germain Fernando (Principal investigator)
Brief description It has been observed that human cancers grow in spite of the presence of tumour antigen specific memory CD8+ tumour killer T cells in the body. These memory killer cells are unable to kill the cancer. Our research work in a mouse model indicates that the CD8+ T cells can be activated to kill cancers if cancer antigen specific CD4+ T helper cells are activated. The mechanism how this happens is not clear. The role of regulatory or suppressor CD4+ T cells are also not known. In this proposal we wish to study the mechanism of how CD8+ memory T cells get activated to cancer killer cells by the CD4+ T helper cells. This information will help us to design better immunotherapies for cancer patients.
Funding Amount $AUD 303,000.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 301084
- PURL : https://purl.org/au-research/grants/nhmrc/301084
