Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/418048]Researchers: Prof Frances Shannon (Principal investigator) , The Australian National University (Managed by)
Brief description The immune system is poised to respond to invading viruses or bacteria and eliminate them as efficiently as possible. Incorrect activation of the immune system leads to chronic inflammation and autoimmunity. Immune cells can also grow in an uncotrolled manner causing leukamia. The cells of the immune system recognise pathogens and respond by altering the patterns of proteins produced by the cells allowing the system to eliminate the invading organisms. The altered protein production patterns stem from changes in the gene expression profile of the cells. The gene expression profile of the cell is determinded by the activity of proteins called transcription factors. One such factor, c-Rel, has been implicated in allergy, autoimmunity, in transplant rejection and in leukemia. The aim of this project is to study the function of c-Rel in T cells, an important cell type in the immune system. The overall aim is to understand how c-Rel controls the gene expression profile of T cells so that a rational basis for c-Rel as a drug target can be designed.
Funding Amount $AUD 531,696.74
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 418048
- PURL : https://purl.org/au-research/grants/nhmrc/418048
