grant

The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron [ 2012 - 2014 ]

Also known as: The role of the disease-related proteins APP and Tau in iron content within the brain

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1025774]

Researchers: Dr James Duce (Principal investigator) ,  A/Pr Paul Adlard

Brief description We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.

Funding Amount $AUD 650,226.63

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Alzheimer disease | Medical and Health Sciences | Neurosciences | Neurology and Neuromuscular Diseases | Parkinson disease | amyloid precursor protein | animal model | disease mechanisms | drug targeting | frontotemporal dementia | iron overload | iron transport | microtubule associated protein (MAP) |
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