[Cite as http://purl.org/au-research/grants/nhmrc/637337]
A/Pr Grant Dewson
Dr Ruth Kluck
Dr Jacqueline Gulbis
Brief description In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak and Bax proteins are members of the Bcl-2 family of apoptosis regulators, and play a pivotal role in mediating cell death. By defining how these proteins form a pore in mitochondria, the point of no return in cell death, will help the development of novel anti-cancer agents that target the Bcl-2 family in general, and Bak and Bax in particular.
Funding Amount $AUD 352,319.12
Funding Scheme NHMRC Project Grants
Standard Project Grant