grant

The role of angiopoietin-1 in the self-renewal and metastasis of prostate cancer stem cells [ 2012 - 2015 ]

Also known as: To study how prostate tumor metastasizes to bone

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1031221]

Researchers: Dr Ming Tat (Patrick) Ling (Principal investigator) ,  Prof Colleen Nelson Prof Judith Clements

Brief description Bone metastasis occurs in more than 80% of cases of advanced prostate cancer (PCa), and is the major cause of morbidity and mortality in PCa patients. Understanding why PCa cells preferentially metastasize to bone may lead to the the development of novel therapy for inhibiting PCa metastasis. This project will study how the bone cell-secreted protein angiopoietin-1 promotes the metastasis of PCa cells to bone and whether inactivation of this protein can inhibit PCa bone metastasis.

Funding Amount $AUD 558,742.40

Funding Scheme Project Grants

Notes Standard Project Grant

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