The role of accessory subunits and assembly factors in the biogenesis of respiratory chain complex I [ 2014 - 2016 ]

Research Grant

Researchers: Prof Michael Ryan (Principal investigator) ,  Prof David Thorburn

Brief description The mitochondrial respiratory chain produces most of the energy required for our cells to grow and function. Complex I is the first enzyme of this chain and its defects are the most prevalent cause of mitochondrial disease, which often results in infant fatality. Defects in complex I have also been associated with Parkinson's disease and oxidative stress. This study will provide important new information into how complex I is built and what goes wrong to cause disease.

Funding Amount $AUD 569,987.20

Funding Scheme Project Grants

Notes Standard Project Grant