The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis [ 2009 - 2011 ]

Also known as: How the ABCA12 protein transporter controls lipid levels and affects the biology of the skin and cardiovascular system

Research Grant

[Cite as]

Researchers: A/Pr Ian Smyth (Principal investigator) ,  Prof Benjamin Kile Prof Dmitri Sviridov

Brief description We have shown that a protein called Abca12 can control the transport of lipids in our bodies. If the function of this gene is attenuated both human and mice develop severe skin disease. Our preliminary results indicate the Abca12 protein regulates cholesterol transport in particular, and this grant will investigate how this might affect normal skin function and contribute to the heart disease atherosclerosis, one of the most common causes of death in the western world.

Funding Amount $AUD 516,401.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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