RNA Polymerase I: A novel target in the treatment of MYC driven malignancies [ 2011 - 2013 ]

Also known as: Pol I and MYC driven malignancy

Research Grant

[Cite as]

Researchers: Prof Ross Hannan (Principal investigator) ,  Prof Grant Mcarthur

Brief description Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be causative in the malignant process. This application will test this hypothesis using novel inhibitors or ribosome biogenesis in a mouse genetic model termed E�-MYC that faithfully that replicates human B-cell lymphoma. These studies will uncover novel mechanisms in malignant transformation and identify new therapeutics in the treatment of human cancer.

Funding Amount $AUD 605,962.99

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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