Reversing antibiotic resistance with efflux pump inhibitors [ 2018 - ]

Research Grant

Researchers: Dr Henrietta Venter (Principal investigator) ,  A/Pr Paolo Ruggerone ,  Prof Klaas Pos ,  Prof Shutao Ma

Brief description Antibiotic resistance in dangerous pathogens is one of the greatest threats to human health of the 21st century. The main cause of multidrug resistance is the presence of drug efflux pumps, which remove antibiotics from the bacterial cell thereby lowering the antibiotic concentration inside the cells to sub-toxic levels. We will use our expertise on these efflux pumps and on how to inhibit them to develop compounds that could reverse resistance and restore the activity of antibiotics.

Funding Amount $487,351.00

Funding Scheme Project Grants

Notes Standard Project Grant