grant

REVEALING MOLECULAR MECHANISMS OF THE SYNCHROTRON RADIATION-INDUCED BYSTANDER EFFECT [ 2012 - 2015 ]

Also known as: Understanding a strange new observation in radiation biology: When a population of cells is irradiated, even un-irradiated “bystanders” neighbours are damaged

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1027558]

Researchers: A/Pr Olga Martin (Principal investigator) ,  Dr Carl Sprung Dr Pavel Lobachevsky

Brief description Radiotherapy, a major treatment for more than half of cancer patients, is based on the dogma that radiation kills targeted cells. The radiation-induced bystander effect, by which the neighbours of irradiated cells can also damaged, is a new paradigm. What is the "danger signal" which induces DNA damage in un-irradiated normal tissues, and what minimal volume of tissue needs to be irradiated to induce bystander damage? The answers could have a major impact on optimising radiotherapy treatment.

Funding Amount $AUD 429,294.40

Funding Scheme Project Grants

Notes Standard Project Grant

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