Relaxin therapy reverses large artery remodelling and stiffening in aged and hypertensive models [ 2011 - 2014 ]

Research Grant

Researchers: A/Pr Xiao-Jun Du (Principal investigator) ,  A/Pr Chrishan Samuel ,  A/Pr Tim Hewitson

Brief description Hypertension and/or ageing result in morphological changes in large arteries with increased stiffness, which impacts negatively to cardiac function and increases the risk of cardiovascular disease. Currently there is no drug that can specifically and rapidly reverse the changes in large arteries. We will study a peptide hormone relaxin as a promising candidate drug in this setting. Our recent study strongly indicate the effectiveness of relaxin in softening stiffened large arteries.

Funding Amount $AUD 444,973.39

Funding Scheme Project Grants

Notes Standard Project Grant