Regulatory T cells and Cardiac Fibrosis in Hypertensive Heart Disease: Cellular and Molecular Mechanisms of Suppression [ 2013 - 2015 ]

Research Grant

Researchers: Prof Alexander Bobik (Principal investigator) ,  A/Pr Peter Tipping ,  Prof Ban-Hock Toh

Brief description Excessive accumulation of collagen in the heart, cardiac fibrosis is a major factor causing heart failure and sudden death. How collagen accumulation occurs in the heart still needs to be elucidated but recent studies in humans and animal models of cardiac fibrosis indicate a significant role for inflammation. The proposed studies are to address this issue and how to regulate inflammation in the heart to suppress cardiac fibrosis, using immune cells called regulatory T cells that suppress inflammation.

Funding Amount $AUD 715,316.35

Funding Scheme Project Grants

Notes Standard Project Grant