Regulatory T cell therapy for prevention of graft versus host disease [ 2018 - ]

Research Grant

Researchers: Prof Barbara Fazekas de St Groth (Principal investigator) ,  Dr Helen McGuire ,  Dr Holly Bolton ,  Prof Derek Hart

Brief description Graft versus host disease (GVHD) is a potentially fatal complication of bone marrow stem cell transplantation for leukaemia and lymphoma. In an animal model of GVHD, we have recently shown 100% effectiveness of treatment with a donor immune cell population, regulatory T cells. We will determine how this therapy works in the animal model. We will use a new technique, mass cytometry, to analyse patient blood samples in preparation for developing regulatory T cell therapy for GVHD.

Funding Amount $754,734.00

Funding Scheme Project Grants

Notes Standard Project Grant