Regulation of TNF expression in inflammation and cancer [ 2017 - ]

Research Grant

Researchers: Dr Philippe Bouillet (Principal investigator) ,  Prof John Silke

Brief description By studying a spontaneous mutation in mice, we have found an error in the TNF gene (a major factor in many inflammatory diseases) that causes severe arthritis, heart valve disease and gut inflammation. We have also identified new regulators of TNF expression, which might be useful therapeutic targets to limit inflammation. We intend to study the role of these regulators in controlling the expression of TNF, and the link between chronic inflammation and the development of cancer.

Funding Amount $728,447.00

Funding Scheme Project Grants

Notes Standard Project Grant