Regulation of the signalling efficiency of the T cell antigen receptor [ 2017 - 2019 ]

Research Grant

Researchers: Prof Katharina Gaus (Principal investigator) ,  Dr Jeremie Rossy

Brief description An immune response starts with activation of the T cell antigen receptor (TCR). How T cell receptor signalling begins, however, is not well understood. We have developed a novel imaging approach that allows us to directly observe what happens after an antigen binds to the receptor. The research will provide mechanistic insights into how T cells sense and discriminate antigens. This knowledge will aid the development of cancer immunotherapies and vaccines.

Funding Amount $AUD 467,127.20

Funding Scheme Project Grants

Notes Standard Project Grant