Regulation of RyR2 channels by calmodulin in healthy and diseased hearts [ 2015 - 2018 ]

Research Grant

Researchers: Prof Derek Laver (Principal investigator) ,  Prof Bjorn Knollmann ,  Prof Dirk Van Helden

Brief description In the heart, RyR2 is responsible for intracellular Ca2+ release. The RyR2 is comprised of a Ca2+ channel and accessory proteins such as CaM that regulate channel activity. Evidence suggests that RyR2 regulation by CaM is altered in heart failure and human arrhythmia syndromes, but there has been no direct evidence for this. We will provide this direct evidence plus determine how CaM regulates RyR2 channels and intracellular Ca2+ release and how this leads to cardiac arrhythmias.

Funding Amount $AUD 614,421.07

Funding Scheme Project Grants

Notes Standard Project Grant