Regulation of ribosomal RNA gene chromatin during malignant transformation. [ 2016 - 2019 ]

Research Grant

Researchers: Prof Ross Hannan (Principal investigator) ,  Dr Elaine Sanij ,  Prof David Tremethick

Brief description The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.

Funding Amount $AUD 909,582.63

Funding Scheme Project Grants

Notes Standard Project Grant