Regulation of regeneration of Dopaminergic neurones in the substantia nigra [ 2002 - 2002 ]

Research Grant

Researchers: Prof Malcolm Horne (Principal investigator) ,  A/Pr David Finkelstein ,  A/Pr John Drago

Brief description Parkinson's Disease (PD) results from the progressive loss of brain cells in the part of the brain called substantia nigra. These brain cells contain a chemical called Dopamine (DA). The symptoms of Parkinson's disease arise when about 80% these DA neurones are lost suggesting that some form of compensation must occur up to this point. In previous studies we have demonstrated that one mechanism for this compensation is through sprouting or branching of the remaining neurones. We have preliminary evidence about the way this is sprouting and regeneration is controlled. The aim of this grant is to explore in detail the mechanisms whereby sprouting is induced and regulated. The significance of this study is that it may provide insights into the way in which regulation of regeneration of the nervous system is controlled. It has specific applications to therapies for Parkinson's disease.

Funding Amount $AUD 115,880.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant