Regulation of monocyte and macrophage functions by leucocyte immunoglobulin-like receptors (LILRs) in human colon [ 2009 - 2013 ]

Also known as: Immune regulatory functions of LILRs-A5, B1 and B4 in human colon

Research Grant

[Cite as]

Researchers: A/Pr Nicodemus Tedla (Principal investigator) ,  E/Pr Carolyn Geczy Prof Michael Grimm

Brief description The human colon contains many bacteria that can invade through a damaged mucosal barrier and provoke immune cells to cause inflammation with their subsequent removal and a rapid shutdown of inflammation. Failure to clear bacteria or inflammation can lead to inflammatory bowel disease or sepsis. We will investigate how new proteins known as Leucocyte Immunoglobulin-like Receptors allow immune cells to effectively clear microorganisms without provoking uncontrolled inflammation

Funding Amount $AUD 295,983.94

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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