Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection [ 2015 - ]

Research Grant

Researchers: Prof Axel Kallies (Principal investigator)

Brief description T cells control infections and cancer cells. During chronic infection or tumor development, however, loss of function of T cells prevents efficient clearing of pathogens or cancer cells, a phenomenon termed T cell ‘exhaustion’. We have found that the regulator protein IRF4 controls cellular nutrient usage, growth and function of T cells and that very amounts of IRF4 occur in T cells during chronic infection. We propose to examine the precise role of IRF4 in chronically stimulated T cells.

Funding Amount $721,046.00

Funding Scheme Project Grants

Notes Standard Project Grant