Regulation of Mesenchymal to Epithelial Transitions by Netrin Receptors [ 2016 - 2019 ]

Research Grant

Researchers: Dr Michael Murray (Principal investigator)

Brief description The formation of 2D cellular sheets is important during development, tissue repair, and tumor growth. The mechanisms involved, however, remain largely unknown. Recent findings in the fly and in human cells suggest Frazzled/Neogenin receptors drive this process, by establishing polarised scaffolds in the cell. We will test this hypothesis using fly genetics and analysis of 3-dimensional culture of mammalian cells. Our results will help guide future therapies for human disease.

Funding Amount $AUD 668,184.62

Funding Scheme Project Grants

Notes Standard Project Grant