Regulation of interleukin-1? activation in inflammatory diseases [ 2013 - 2015 ]

Research Grant

[Cite as]

Researchers: Dr James Vince (Principal investigator) ,  Dr Kate Lawlor

Brief description IL-1? protein is required to combat infection but also contributes to inflammatory diseases, such as Rheumatoid arthritis and diabetes. Understanding how IL-1? is produced is therefore critical to the development of better therapeutics for these conditions. We have identified a new pathway involving the protein RIP3 that can cause IL-1? activation. This project will examine how this pathway is molecularly regulated and determine its importance in inflammatory disease models.

Funding Amount $AUD 624,429.36

Funding Scheme Project Grants

Notes Standard Project Grant

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