Regulation of inflammation and coagulation by microparticles containing SerpinB2 [ 2013 - 2015 ]

Research Grant

Researchers: Prof Andreas Suhrbier (Principal investigator) ,  A/Pr Elizabeth Gardiner ,  A/Pr Robert Andrews ,  Dr Wayne Schroder

Brief description SerpinB2 is a protein that is abundant during many types of inflammation. However, what this protein actually does remains an enigma. We have found that SerpinB2 is associated with microparticles; small particles found in everyone’s blood, that are used by cells to communicate with each other. We believe inappropriate levels of SerpinB2 on these microparticles change both inflammation and blood clotting; a contention with implications for several diseases including pre-eclampsia and cancer.

Funding Amount $AUD 594,133.70

Funding Scheme Project Grants

Notes Standard Project Grant