Regulation of immune mechanisms by pathogen cysteine proteases [ 2008 - 2011 ]

Also known as: Understanding the mechanisms of parasite immune suppression

Research Grant

[Cite as]

Researchers: Prof John Dalton (Principal investigator) ,  Dr Sheila Donnelly

Brief description To survive, parasites have evolved many strategies to control the human immune system. We have identified an enzyme secreted by parasites that can manipulate cells of the immune system, subsequently preventing the development of inflammatory responses. We will investigate the mechanism involved and determine whether this enzyme could be exploited for therapeutic purposes to switch off inflammation in autoimmune disease such as type-1 diabetes.

Funding Amount $AUD 424,676.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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