Regulation of HIV-1 Tat Trafficking in cells [ 2009 - 2011 ]

Research Grant

Researchers: A/Pr David Harrich (Principal investigator) ,  Prof Monsef Benkirane

Brief description AIDS is caused by the human immunodeficiency virus type 1 (HIV-1). Long-term HIV infection leads to increased incidence of Kaposi's sarcoma, AIDS dementia complex, and immune dysfunctions. The HIV-1 Tat protein has been linked to disease progression. However, Tat is predominantly found in the cell nucleus while measurable levels in patient serum. This is not believed to be a passive event caused by dying cells. Here we will investigate how Tat is released by HIV-1 infected cells.

Funding Amount $AUD 494,489.51

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant