Regulation of heart development and regeneration by DNA methylation. [ 2015 - ]

Research Grant

Researchers: A/Pr Enzo Porrello (Principal investigator) ,  Dr James Hudson ,  Prof Assam El-Osta

Brief description The adult mammalian heart has an extremely limited capacity for regeneration following a heart attack, which is in stark contrast to the robust regenerative capacity of the newborn heart. How and why mammals lose their ability to regenerate heart tissue after birth is not well understood. We propose a new approach to unravel the complex mechanisms that control gene expression during heart development in rodents and humans, which could provide new therapeutic avenues for heart regeneration.

Funding Amount $535,616.00

Funding Scheme Project Grants

Notes Standard Project Grant