The regulation of gene expression during adipogenesis [ 2007 - 2009 ]

Research Grant

Researchers: Prof Merlin Crossley (Principal investigator) ,  A/Pr Gareth Denyer ,  Dr Kim Bell-Anderson

Brief description The body stores energy acquired from ingested food as fat droplets within storage cells termed adipocytes. The amount of fat varies between individuals and may also vary during an individual's life. The variations reflect differences in physiology, diet, and behaviour and have been the focus of intense study. Excessive accumulation of fat is a serious health problem as it is associated with conditions such as heart disease and diabetes. This grant application primarily concerns using a new line of genetically modified mice that have reduced fat. These mice lack a key gene regulatory protein that is implicated in fat accummulation and adipocyte formation. It is expected that a knowledge of the genes regulating the formation and function of fat storage cells will contribute to new strategies for controlling fat formation and will help in the prevention of diseases such as diabetes and heart disease.

Funding Amount $AUD 549,446.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant