grant

Regulation of gastric tumour invasion and growth by gp130 activating cytokines. [ 2007 - 2009 ]

Also known as: Cytokines regulate stomach tumours

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/454543]

Researchers: Prof Andrew Giraud (Principal investigator) ,  Dr Louise Judd

Brief description Gastric cancer is a major cause of morbidity and death worldwide. We have previously established a very informative animal model of this disease which has facilitated a new understanding of the diverse role of the IL-6 family of cytokines in regulating gastric tumour growth and dissemination to distant organs. This proposal will focus on how the main members of this cytokine family, namely IL-6 and IL-11, inhibit gastric tumour invasion to other organs, and promote tumour growth respectively . An understanding of these processes will aid in designing therapeutic interventions specific for each cytokine and which may lead to drugs aimed at limiting or reversing this disease.

Funding Amount $AUD 625,642.36

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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