grant

Regulation and function of the Zinc-finger protein ASCIZ in the DNA damage response [ 2012 - 2014 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1026125]

Researchers: A/Pr Jorg Heierhorst (Principal investigator)

Brief description Each human cell is exposed to more than 10,000 spontaneous DNA damage events per day. Inaccurate repair of this is damage is believed to be one of the key events in the onset of cancer. We have discovered a protein called ASCIZ that contributes to the repair of DNA base damage, and also has a separate function in the onset of lung development. Here we want to study in detail the mechanism of how it functions in DNA repair and thereby keeps mutation rates low and prevents the onset of cancer.

Funding Amount $AUD 640,101.33

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857