Regulation of expression of the microRNA-200 family [ 2008 - 2010 ]

Research Grant

Researchers: Prof Gregory Goodall (Principal investigator) ,  A/Pr Andrew Ruszkiewicz ,  A/Pr Yeesim Khew-Goodall ,  Prof Frances Shannon

Brief description The majority of deaths from cancer are due to tumour metastasis. To metastasize, tumour cells must convert to a migratory form that can allow tumor cells to migrate and disseminate in the body. This process requires a genetic reprogramming of the cell. We have discovered that this genetic reprogramming is under the control of small RNA molecules called microRNAs. In this project we investigate what controls the levels of the microRNAs, to allow metastasis to occur in colon tumours.

Funding Amount $AUD 573,557.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant