Regulation of the epithelial sodium channel by cytosolic chloride and pro-inflammatory cytokines [ 2003 - 2005 ]

Research Grant

Researchers: A/Pr Anuwat Dinudom (Principal investigator) ,  Prof David Cook ,  Prof John Young

Brief description The regulation of sodium transport by the epithelial sodium channel is essential for the maintenance of blood pressure and the correct amount of fluid in the respiratory tract and gut. Hyperactivity of the sodium channels leads to increased blood pressure and clogging of the gut and bronchi due to dehydration of the surface fluid. Reductions in the activity of the sodium channels lead to abnormally low blood pressure and the accumulation of fluid in the lungs such as occurs in influenza, high altitude pulmonary oedema and in cardiogenic pulmonary oedema. The present project will examine the mechanisms by which sodium channels are regulated. It will focus on the mechanisms by which cytosolic chloride and inflammatory mediators regulate the activity of the channels.

Funding Amount $AUD 219,750.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant