[Cite as http://purl.org/au-research/grants/nhmrc/1006428]
Dr Yuekang Xu
Prof Jose Villadangos
Prof Paul Gleeson
Brief description Proteases can contribute to atherosclerosis, so they are normally controlled by the endogenous inhibitor, Cystatin C (Cst C). Some conditions cause reduction in Cst C levels and hence disease. On the other hand, excess Cst C can form toxic aggregates. In this project, we will identify mechanisms controlling Cst C expression and aggregation to find therapeutic strategies to treat cardiovascular diseases associated with Cst C.
Funding Amount $AUD 498,505.02
Funding Scheme NHMRC Project Grants
Standard Project Grant