Regulation of the Cardiovascular Disease-Associated Protease Inhibitor Cystatin C for Therapeutic Application [ 2011 - 2013 ]

Also known as: Regulation of Protease Inhibitor Cystatin C for Therapeutic Application

Research Grant

[Cite as]

Researchers: Dr Yuekang Xu (Principal investigator) ,  Prof Jose Villadangos (Principal investigator) ,  Prof Paul Gleeson

Brief description Proteases can contribute to atherosclerosis, so they are normally controlled by the endogenous inhibitor, Cystatin C (Cst C). Some conditions cause reduction in Cst C levels and hence disease. On the other hand, excess Cst C can form toxic aggregates. In this project, we will identify mechanisms controlling Cst C expression and aggregation to find therapeutic strategies to treat cardiovascular diseases associated with Cst C.

Funding Amount $AUD 498,505.02

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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