Regulation of bone resorption and formation in health and disease [ 2005 - 2009 ]

Research Grant

Researchers: E/Pr Thomas Martin (Principal investigator) ,  A/Pr Kong Ng ,  A/Pr Natalie Sims ,  Prof Matthew Gillespie

Brief description Bone is continually being formed and broken down, and these two processes are critical forthe maintenance of a normal skeleton. These processes are dependent upon communication between the bone building and degrading cells, and the hormones growth factors and cytokines that are present in the circulation or produced in bone. The tightly regulated processes of bone formation and degradation need to remain equal, and are essential for the achievement and maintenance of skeletal strength and form. Osteoporosis results from an excess of bone breakdown over formation, and our Program aims to identify the factors that regulate these processes, and develop new therapies that can modify them. We will also determine what it is about bone cell properties that make some cancers, especially those of breast and prostate, particularly prone to spread to bone.

Funding Amount $AUD 5,596,183.00

Funding Scheme Programs

Notes Program Grant