Regulation of amyloid-beta production by glycosphingolipid synthesis inhibition [ 2009 - 2012 ]

Also known as: A new drug for Alzheimers disease

Research Grant

[Cite as]

Researchers: Prof Brett Garner (Principal investigator) ,  Dr Genevieve Evin

Brief description Alzheimer's disease (AD) prevalence is rising and there is currently no curative treatment. Production of neurotoxic amyloid-beta peptide (Abeta) in the brain is thought to be one causative factor in AD. We have recently discovered a new drug that alters lipid levels in cell membranes and potently inhibits Abeta production by neurons. We will define precisely how this drug works and examine its potential to reduce Abeta accumulation in the brains of mice genetically engineered to mimic AD.

Funding Amount $AUD 549,925.23

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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