Regulation of the activity and the surface expression of sodium channels [ 2002 - 2004 ]

Research Grant

Researchers: Prof David Cook (Principal investigator) ,  Prof John Young

Brief description The regulation of transport of salt into and out of the body is essential for the maintenance of blood pressure, and for the maintenance of the correct amount of fluid in the respiratory passages and gut. A critical component of the mechanism by which the body transports salt are sodium channels. Overactivity of these channels leads to increased blood pressure and clogging of the gut and the bronchi due to thick and sticky secretions. Reduced activity leads to abnormally low blood pressure, as well as to accumulation of fluid in the lungs such as occurs in influenza and in altitude sickness. The present project will examine the mechanisms by which sodium channels are regulated. It will particularly focus on the mechanisms by which sodium channels are switched off when the salt content of cells is too high.

Funding Amount $AUD 466,980.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant