Regulation of the actin cytoskeleton by miR-200 [ 2011 - 2013 ]

Research Grant

Researchers: Prof Gregory Goodall (Principal investigator) ,  A/Pr Andrew Ruszkiewicz ,  A/Pr Yeesim Khew-Goodall ,  Dr Cameron Bracken ,  Prof Alpha Yap

Brief description The migration of cancer cells (metastasis) is responsible for most cancer deaths. Central to this is dynamic organisation of the actin cytoskeleton _ an internal structure that provides cell shape and enables movement. We have identified a family of small molecules (called miR-200) that regulates this actin cytoskeleton through specifically downregulating various genes. We are investigating the nature of these genes and their role in cell motility _ an underlying pre-requisite of metastasis.

Funding Amount $AUD 540,356.57

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant