Regulating astrocytosis for appropriate defence and repair of the brain after injury [ 2012 - 2015 ]

Research Grant

Researchers: A/Pr David Nisbet (Principal investigator) ,  A/Pr John Forsythe ,  Prof Malcolm Horne ,  Prof Philip Beart ,  The Australian National University (Managed by)

Brief description An inflammatory process, designed to clean up cell debris and maintain tissue integrity following brain insult, also results in an astrocytic scar that biochemically impedes nerve repair. After 8 weeks astrocytes switch to become supportive, however once a scar is formed repair is permanently inhibited. Here, we will test the ability of biomaterials to optimise the timing of the necessary inflammatory phase, to encourage repair by converting astrocytes to their tropic phase more rapidly.

Funding Amount $AUD 562,742.09

Funding Scheme Project Grants

Notes Standard Project Grant