Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells [ 2009 - 2012 ]

Also known as: Regulation of beta-catenin location and function

Research Grant

[Cite as]

Researchers: A/Pr Beric Henderson (Principal investigator)

Brief description Inherited gene mutations that cause colon cancer kill 4,700 Australians every year. About 1 in 21 Australians develop colorectal cancer by age 75. Activation of the beta-catenin protein is a critical switch in the path to colon cancer. We discovered that beta-catenin, and another protein it interacts with called IQGAP1, move between different cellular compartments. We plan to study this process in more detail, as it relates to how beta-catenin works and to understanding its role in cancer.

Funding Amount $AUD 511,703.14

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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