How do red blood cells enucleate? [ 2009 - 2011 ]

Research Grant

Researchers: Prof Patrick Humbert (Principal investigator)

Brief description Removal of the nucleus from red blood cells (enucleation) is essential for proper circulation of red blood cells through the microvasculature and high haemoglobin concentration in the blood. How this fundamental process is achieved is surprisingly poorly understood. Here we propose to investigate how enucleation occurs in light of enucleation being an unusual asymmetric division. These studies are likely to lead to improvements in expansion of human red blood cells in vitro for transfusions.

Funding Amount $AUD 581,892.59

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant