Reappraisal of the mechanisms underlying implantation success or failure [ 2018 - 2020 ]

Research Grant

Researchers: Prof Lois Salamonsen (Principal investigator) ,  Dr David Greening ,  Dr Jemma Evans ,  Prof Beverley Vollenhoven ,  Prof Richard Simpson

Brief description Infertility affects 1:6 Australian couples; these seek help. However, for each IVF cycle, there is only ~18.5% chance of a live birth, significantly due to failure of embryo implantation. We discovered nano-vesicles in the uterine cavity, that are released from the womb lining and taken up by the pre-implantation embryo to improve its implantation potential. We will determine how this extracellular environment can enhance implantation success and circumvent/management of infertility.

Funding Amount $AUD 761,265.36

Funding Scheme Project Grants

Notes Standard Project Grant